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GEN – Genetic Engineering and Biotechnology NewsHomeWebinarsUpcomingRight Resin, Right Order: A Two-Step Polishing Strategy for Bispecific Antibodies
Credit: Volodymyr Kalyniuk / iStock / Getty Images Plus
Emily Gaither
Engineer III, Downstream Purification
Thermo Fisher Scientific
Panelist
Emily Gaither
Emily Gaither is a bioprocessing engineer specializing in downstream purification at Thermo Fisher Scientific. She has over five years of experience in downstream process development, with expertise in downstream process development, characterization, scale up and manufacturing implementation. Prior to joining Thermo Fisher Scientific in 2021, Emily worked at the University of Illinois Urbana-Champaign, where she supported bioengineering research and laboratory automation. Emily holds a bachelor’s degree in biology from North Central College.
Broadcast Date:Thursday, October 8, 2026
- Time:08:00 PDT, 11:00 EDT, 17:00 CET
Bispecific antibodies can create purification challenges that conventional monoclonal antibody platform polishing is not always equipped to solve, with product-related variants “misbehaving” and closely resembling the desired heterodimer. Effective and efficient process development depends not only on identifying the appropriate selectivity from a toolbox of chromatography resins, but also how efficiently complementary unit operations interconnect for manufacturing.
In thisGENwebinar, our expert speaker, Emily Gaither, will present a systematic path from high-throughput resin screening to the selection and sequencing of two polishing steps, using emicizumab, an asymmetric IgG4 bsAb as a case study. She will compare alternative process configurations and examine the purity, recovery, and process-performance tradeoffs used to identify a preferred downstream polishing train. Key takeaways from the webinar include:
- A systematic approach to screening polishing resins for bsAbs
- Strategies for matching resin selectivity to key impurities
- Insights into how polishing resin selection affects process performance
- Criteria for balancing purity, yield, loading, and robustness
A live Q&A session will follow the presentation, offering you a chance to pose questions to our expert panelist.
Produced with support from:
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